Do not use if you are pregnant or breastfeeding. If symptoms persist or worsen, consult a health professional. May cause gastrointestinal discomfort such as constipation, vomiting, abdominal pain or diarrhea; in which case, discontinue use and consult a health professional. Consult a health professional prior to use if you have diabetes, cardiovascular disease, liver or kidney disease, leucopenia, or hypertension or hypotension; if you have gall stones; or if you are taking prescription medications, as berberine may alter the effectiveness of these medications. Keep out of reach of children. Do not use if security seal inside the cap is broken. Store tightly sealed in a cool, dry place.