A high level of homocysteine in circulation is an independent risk factor for the development of disability and death from cardiovascular disease (CVD) including stroke. CVD risk increases proportionately by 6 to 7% with every 1 µmol/L increase in blood homocysteine. Elevated blood homocysteine is also thought to relate to onset of diseases of the brain and kidneys and to diabetic complications. Elevated homocysteine levels are often observed in the elderly and in individuals with compromised nutrition, gastrointestinal disorders or a genetic tendency for hyperhomocysteinemia. Methyl SAP provides a combination of scientifically supported doses of B vitamins (folate, vitamin B₆, vitamin B₁₂).