Consult a Health care practitioner if pregnant or breastfeeding, you have malignant neoplasms, serious infections, psychiatric disorders, ophthalmic disorders, metabolic diseases, malignant tumors, cardiac failure, or myocardial infarction. Consult a health care practitioner if taking prescription medication or natural health supplement. Consult a health care practitioner if you have a history of serious hepatic, renal, cardiac, pulmonary, or gastrointestinal diseases. Do not take vitamin B3 or related products with this product. Consult a health care practitioner prior to use if you have diabetes.